Metrics details. Metastases to the thyroid gland are more frequent than previously thought, although most of them are occult or not clinically relevant. Overall, only 42 cases of metastases to thyroid from breast cancer have been reported thus far. Here we report the case of a patient with breast cancer metastatic to the thyroid.
Breast cancer BC and thyroid cancer TC are common malignancies among females. However, the connection between TC and BC is not well understood. We extracted data from patients with only BC or TC and from BC patients with a second metachronous cancer from — Differences in the clinicopathological and treatment characteristics between BC patients with or without second metachronous TC were analyzed by chi-square tests. Multivariate analyses of BC survival were performed by using Cox regression models. Comparison of disease-specific survival DSS curves between these cohorts was performed with the log-rank Mantel-Cox test.
The Breast-Thyroid Cancer Link: A Systematic Review and Meta-Analysis
Rates of thyroid cancer in women with a history of breast cancer are higher than expected. Similarly, rates of breast cancer in those with a history of thyroid cancer are increased. Explanations for these associations include detection bias, shared hormonal risk factors, treatment effect, and genetic susceptibility. With increasing numbers of breast and thyroid cancer survivors clinicians should be particularly cognizant of this association. Here we perform a systematic review and meta-analysis of the literature utilizing PubMed and Scopus search engines to identify all publications studying the incidence of breast cancer as a secondary malignancy following a diagnosis of thyroid cancer or thyroid cancer following a diagnosis of breast cancer.
As more people are being diagnosed with thyroid cancer, and survival rates are generally excellent, there are more survivors of thyroid cancer. Previous studies done in patient populations from a small number of institutions showed an increased risk for breast cancer in women with a history of thyroid cancer. The cause for this is unclear, but genetic changes, radiation exposure, and hormonal factors have been considered. It was also done to further explain the elevated risk for breast cancer in female survivors of thyroid cancer.